Incidental findings and secondary findings, being results that are unrelated to the diagnostic question, are the subject of an important debate in the practice of clinical genomic medicine. Arguments for reporting these results or not doing so typically relate to the principles of autonomy, non-maleficence and beneficence. However, these principles frequently conflict and are insufficient by themselves to come to a conclusion. This study investigates empirically how ethical principles are considered when actually reporting IFs or SFs and how value conflicts (...) are weighed. A qualitative focus group study has been undertaken, including a multidisciplinary group of professionals from Belgian centres for medical genetics. The data were analysed thematically. All eight Belgian centres participated in this study. Ethical values were frequently referred to for disclosure policies on IFs and SFs. Participants invoked respect for patient autonomy to support the disclosure of IFs and opt-out options for IFs and SFs, non-maleficence for the professional delineation of reportable IFs and opt-out options for IFs and SFs and beneficence for the mandatory reporting of actionable IFs, the delineation of reportable IFs and a current decline of actively pursued SFs. Professional assumptions about patients’ genetic literacy were an important factor in the weighing of values. In line with the traditional bioethical discourse, the mandatory reporting of actionable IFs might be interpreted as a “technological, soft paternalism”. Restricting patients’ choices might be acceptable, but then its motives should be valid and its beneficent outcomes highly plausible. Hence, the presuppositions of technological, soft paternalism - patients’ inability to make informed decisions, normative rationality, the efficacy of beneficent outcomes and the delineated spectrum of beneficence - should be approached critically. Moreover, distributive justice should be considered an important value in the delineation of the current scope of the ethical debate on IFs and SFs. This study of guiding values may stimulate the debate on the ethical grounds for a solid policy on IFs and SFs internationally. (shrink)

It is shown that the violation of Bell's inequality allowed by quantum mechanics and the related Bell's theorem without inequalities is accounted for by local commutations of operators representing single-particle observables. It is argued that the idea of nonlocal influencing of one particle on another when they are in spacelike separated regions clearly has neither empirical nor theoretical support.

The empirical validity of the locality (LOC) principle of relativity is used to argue in favour of a local hidden variable theory (HVT) for individual quantum processes. It is shown that such a HVT may reproduce the statistical predictions of quantum mechanics (QM), provided the reproducibility of initial hidden variable states is limited. This means that in a HVT limits should be set to the validity of the notion of counterfactual definiteness (CFD). This is supported by the empirical evidence that (...) past, present, and future are basically distinct. Our argumentation is contrasted with a recent one by Stapp resulting in the opposite conclusion, i.e. nonlocality or the existence of faster-than-light influences. We argue that Stapp’s argumentation still depends in an implicit, but crucial, way on both the notions of hidden variables and of CFD. In addition, some implications of our results for the debate between Bohr and Einstein, Podolsky and Rosen are discussed. (shrink)

The validity of the conclusion to the nonlocality of quantum mechanics, accepted widely today as the only reasonable solution to the EPR and Bell issues, is questioned and criticized. Arguments are presented which remove the compelling character of this conclusion and make clear that it is not the most obvious solution. Alternative solutions are developed which are free of the contradictions related with the nonlocality conclusion. Firstly, the dependence on the adopted interpretation is shown, with the conclusion that the alleged (...) nonlocality property of the quantum formalism may have been reached on the basis of an interpretation that is unnecessarily restrictive. Secondly, by extending the conventional quantum formalism along the lines of Ludwig and Davies it is shown that the Bell problem may be related to complementarity rather than to nonlocality. Finally, the dependence on counterfactual reasoning is critically examined. It appears that locality on the quantum level may still be retained provided one accepts a newly proposed principle of nonreproducibility at the individual quantum level as an alternative of quantum nonlocality. It is concluded that the locality principle can retain its general validity, in full conformity with all experimental data. (shrink)

The Ukrainian photographer Sergey Bratkov started his career in 1987 with his first solo shows in Kharkiv, Cheb, and Tel Aviv. He has since enjoyed international recognition from solo and group exhibitions in Europe an.

We re-examine Peres' statement “opposite momenta lead to opposite directions”. It will be shown that Peres' statement is only valid in the large distance or large time limit. In the short distance or short time limit an additional deviation from perfect alignment occurs due to the uncertainty of the location of the source. This error contribution plays a major role in Popper's orginal experimental proposal. Peres' statement applies rather to the phenomenon of optical imaging, which was regarded by him as (...) a verification of his statement. This is because this experiment can in a certain sense be seen as occurring in the large distance limit. We will also reconsider both experiments from the viewpoint of Bohmian mechanics. In Bohmian mechanics particles with perfectly opposite momenta will move in opposite directions. In addition it will prove particularly useful to use Bohmian mechanics because the Bohmian trajectories coincide with the conceptual trajectories drawn by Pittman et al. In this way Bohmian mechanics provides a theoretical basis for these conceptual trajectories. (shrink)

German nouns may alternate from singular to plural in two different ways. Some singular forms that end in a voiceless obstruent have a plural in which this obstruent is voiced. Another alternation concerns the vowel. Some singular forms with a back vowel have a plural form in which this back vowel is front. For each noun it has to be established individually whether it alternates or not. The voicing alternation is phonetically grounded, but the vowel alternation is not. Knowledge about (...) such alternations involves two things. First, it involves knowledge of which words alternate and which words do not and second, it involves the ability to extend the alternations to novel words. We studied the knowledge of which words alternate and the proportion to which they alternate in two corpus studies. We studied the knowledge of speakers concerning which words alternate and what generalizations can be based upon these words by means of a production study. The production study involved words and nonces. We asked twenty 5 year-olds, twenty 7 year-olds and tenth adults to produce the plural for a given singular word and a plural for a given singular nonce. In the corpus study we found that both alternations occur with the same frequency. In the production of alternations in words we found that participants in all age groups make few mistakes. With respect to the production of alternations in nonce words, we found that the proportion of voicing alternations decreases with age, while the proportion of vowel alternations increases. We explain this change in the ability to generalize the alternations to nonces on the basis of the confidence speakers can have in a generalization. Young children have a small lexicon and they can form relatively unreliable generalizations on lexical distributions, but they can have more confidence in their knowledge of phonetics. Adults have a large lexicon and can therefore confidently form based on their lexicon. (shrink)

Using the artificial language paradigm, we studied the acquisition of morphophonemic alternations with exceptions by 160 German adult learners. We tested the acquisition of two types of alternations in two regularity conditions while additionally varying length of training. In the first alternation, a vowel harmony, backness of the stem vowel determines backness of the suffix. This process is grounded in substance (phonetic motivation), and this universal phonetic factor bolsters learning a generalization. In the second alternation, tenseness of the stem vowel (...) determines backness of the suffix vowel. This process is not based in substance, but it reflects a phonotactic property of German and our participants benefit from this language-specific factor. We found that learners use both cues, while substantive bias surfaces mainly in the most unstable situation. We show that language-specific and universal factors interact in learning. (shrink)

© 2016 Regents of the University of California.The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,062 new measurements from 721 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. All the particle properties and search limits are listed in Summary Tables. We also give numerous (...) tables, figures, formulae, and reviews of topics such as Higgs Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology, Particle Detectors, Colliders, Probability and Statistics. Among the 117 reviews are many that are new or heavily revised, including those on Pentaquarks and Inflation. The complete Review is published online in a journal and on the website of the Particle Data Group. The printed PDG Book contains the Summary Tables and all review articles but no longer includes the detailed tables from the Particle Listings. A Booklet with the Summary Tables and abbreviated versions of some of the review articles is also available. (shrink)

As more young people feel safe to outwardly identify as transgender or gender expansive (TGE), meaning that their gender identity does not align with the sex they were assigned at birth, an increasing number of youth who identify as TGE seek gender-affirming medical care (GAMC). GAMC raises a number of ethical questions, such as the capacity of a minor to assent or consent, the role of parents or legal guardians in decisions about treatment, and implications for equitable access to care (...) when differing parental or custodial viewpoints are present. These questions are further complicated by the difficulties in explaining the limits of long-term research in GAMC, with regard to the preservation of fertility, for example. We present two de-identified composite case studies to highlight dilemmas that may arise and offer recommendations to better support patient- and family-centered decision making for GAMC. These include employing a multidisciplinUniverary shared decision-making approach, disentangling informed consent and assent from chronological age, developing a consistent approach to the assessment of decisional capacity, and developing age-appropriate informational materials. (shrink)

This volume features Reid’s previously unpublished manuscripts on natural history, physiology, and materialism. The manuscripts, over 150 pages of new material, follow a lengthy introduction in which Reid’s philosophical orientation and opponents are nicely laid out. What would otherwise be a narrowly informative reading of the Natural History manuscripts, that is, Reid’s notes to himself on Buffon’s Histoire Naturelle and Bonnet’s Contemplation de la Nature, is instead illuminated by Wood’s tour of the relevant eighteenth-century debates. Wood achieves this by indicating (...) that Reid’s interest in botany derived from his goal of showing that the vital functions of plants depended on immaterial causes. Also informative are selections from Reid’s correspondence with Lord Kames on the issue of whether unthinking matter could be self-organizing, and the chronicling of Reid’s development on the subject of generation, which paralleled Bonnet. (shrink)

Recognition of legal personhood in contemporary international and domestic law is a matter of signs. Those signs identify the existence of the legal person: human animals, corporations and states. They also identify facets of that personhood that situate the signified entities within webs of rights and responsibilities. Entities that are not legal persons lack agency and are thus invisible. They may be acted on but, absent the personhood that is communicated through a range of indicia and shapes both legal and (...) popular understanding of powers and obligations, they lack standing in judicial fora. They are signified as entities that are the subjects of action by legal persons, for example exploitation through rights regarding natural resources or commodification of ‘wild’, companion and other non-human animals. They are also signified as members of a diverse class of non-persons such as ‘nature’ and ‘the environment’. This article explores the consequences of law’s signification of personhood and the natural world before asking whether we both should and could recognise domains such as specific rivers, forests or even Antarctica as a type of legal person. Recognition might acknowledge the salience of nature in the ontologies of colonised First Peoples. It might also underpin a global response to climate change as the existential crisis of the Anthropocene. In understanding law as a matter of signifiers and syntaxes the article cautions that ostensible recognition of some domains as persons has been aspirational rather than substantive, with observers misreading the sign as necessarily transforming power relationships. The article also cautions that personhood for nature or particular domains may be contrary to the self-determination of colonised First Peoples. (shrink)

This text slightly modified, became the first chapter of our M.A. thesis - The Tropical Phoenix: a critical note about dualism and the theory of dependency, presented to the "Faculdade de Filosofia, Letras e Ciências Humanas" of the University of São Paulo. The main themes of this thesis are: I - "Philosophy of History", Marxism and "objectivity"; II - Brazilian social thinking: the theories of/about development and the apologetic Marxism: 1.º Werner Baer: conservative "objectivity" against the reformist "passions"; 2.º Carlos (...) Lessa: Industrialization as "decision"; 3.º ISEB: reformist objectivity against socialist passions; 4.º Political maturity against socialist adventures; III - Common presuppositions.Este texto veio a constituir, modificado, o primeiro capítulo de nossa tese de mestrado - A Fênix tropical: nota crítica sobre o dualismo e a teoria da dependência, Faculdade de Filosofia, Letras e Ciências Humanas, Universidade de São Paulo. Trata dos seguintes temas: I - A "filosofia da história", o marxismo e a "objetividade"; II - O pensamento social brasileiro: as teorias do/sobre o desenvolvimento e o marxismo apologético: 1.º Werner Baer: a "objetividade" conservadora contra as "paixões" reformistas; 2.º Carlos Lessa: Industrialização como "decisão"; 3.º ISEB: objetividade reformista contra paixões socialistas; 4.º Maturidade política contra aventuras socialistas; III - Os pressupostos comuns. (shrink)

Se editan los textos centrales de la conferencia pronunciada en 1860 por K. E. y. Baer, según la rara edición que hizo de la misma en ¡862. Su mostración imaginativa de lo diferente que sería nuestra representación de la realidad natural con el USO de otros cánones espacio-temporales, puede volver a interesar hoy, sobre todo, al llamado Constructivismo,Zentrale Texte des Vortrages von 1860, den It E. y. Baer lii Petesbrug hielt, nach der seltenen Ausgabe von 1862, sowie ibre spanische Ubersetzung (...) sind hier herausgegeben. Seine imaginative Darstellung der ganz verschiedenen Auffasung der Natur nach der Veránderung des Raum-Zeit-Mai3stabes gelten jinmer noch als Anregung ciner fruchtbaren Reflexion, tiberhaupt in Zeiten des sogenannten Konstruktivismus. (shrink)

In this paper we enrich the orthomodular structure by adding a modal operator, following a physical motivation. A logical system is developed, obtaining algebraic completeness and completeness with respect to a Kripkestyle semantic founded on Baer*-semigroups as in [22].

Seven unknown letters from 1823 to 1831 are published. The famous discoverer of the mammal's egg and founder of the modern embryology Karl Ernst von Baer (1792–1876), born as a German in Estonia and then anatomist and zoologist at Königsberg University, wrote them to his publisher Ludwig F. Froriep in Weimar and his son and successor. Robert F. Baer offered his co-work with a dictionary of natural history (which he criticized), he proposed a map of all research voyages everywhere in (...) the world, and he sent a few small papers about local birds. To Robert F. Baer gave some recommendations concerning his career; he asked for details of a death elephant, and he told that they were awaiting the cholera. (shrink)

Early zoological researches by P.S. Pallas and K.E. von Baer in their letters to the zoologists of Berlin. The centenaries which are celebrated in 1991 and 1992 in memory of P.S. Pallas (1791) and K.E. von Baer (born 1792) caused the following studies of hitherto unpublished sources, preserved in the collections of the Museum für naturkunde in Berlin. The earliest zoological works of Pallas are discussed in relation to his last publication on the “Zoographia Rosso-Asiatica” which should have been finished (...) in Berlin. Some years after the death of Pallas, Baer also contacted the Berlin zoologists K.A. Rudolphi and M.H. Lichtenstein, asking for help, when he was going to establish zoology and a zoological museum at the University of Königsberg. (shrink)

A word often expresses many different morphological functions. Which part of a word contributes to which part of the overall meaning is not always clear, which raises the question as to how such functions are learned. While linguistic studies tacitly assume the co-occurrence of cues and outcomes to suffice in learning these functions (Baer-Henney, Kügler, & van de Vijver, 2015; Baer-Henney & van de Vijver, 2012), error-driven learning suggests that contingency rather than contiguity is crucial (Nixon, 2020; Ramscar, Yarlett, Dye, (...) Denny, & Thorpe, 2010). In error-driven learning, cues gain association strength if they predict a certain outcome, and they lose strength if the outcome is absent. This reduction of association strength is called unlearning. So far, it is unclear if such unlearning has consequences for cue–outcome associations beyond the ones that get reduced. To test for such consequences of unlearning, we taught participants morphophonological patterns in an artificial language learning experiment. In one block, the cues to two morphological outcomes—plural and diminutive—co-occurred within the same word forms. In another block, a single cue to only one of these two outcomes was presented in a different set of word forms. We wanted to find out, if participants unlearn this cue's association with the outcome that is not predicted by the cue alone, and if this allows the absent cue to be associated with the absent outcome. Our results show that if unlearning was possible, participants learned that the absent cue predicts the absent outcome better than if no unlearning was possible. This effect was stronger if the unlearned cue was more salient. This shows that unlearning takes place even if no alternative cues to an absent outcome are provided, which highlights that learners take both positive and negative evidence into account—as predicted by domain general error-driven learning. (shrink)

This mixed-method design aimed to determine how practicing mindfulness in a high school classroom influences students’ academic focus and affective experience. Thirty-nine tenth-grade students participated in an eight-week intervention, in which they practiced mindfulness activities led by their certified English and yoga teacher once per week. Students completed a pre- and posttest Likert-scale survey to measure mindfulness using Greco, Baer, and Smith’s Child and Adolescent Mindfulness Measure (CAMM) as well as three, open-ended post-test reflection questions. The survey data were analyzed (...) to assess change in mindfulness and change in focus, and the qualitative data were analyzed to understand students’ self-perceptions of their affective experience. Results show that students’ scores for both mindfulness and focus increased after the intervention and they also show that students made gains in self-knowledge. The findings provide implications for educators to improve their classroom environments and reduce their own stress. (shrink)

Following the publication of 7 letters from Baer to the Frorieps by H.E. Müller-Dietz inNTM N.S. 1 (1993), 2 further letters from Baer and 8 from the Frorieps are published. A curious technical problem in the presentation of the journalNotizen published by Froriep in his Landes-industriecomptoir in Weimar is discussed at length. Froriep recommends his son Robert, to whom Baer sends several enquiries and commissions, which Robert deals with carefully (1831 in Jena, 1849 in Paris). Robert explains in great detail (...) his intention to leave Jena for Berlin in 1831. After his father's death in 1847 he returns to take charge of the Landesindustriecomptoir and begins to cooperate with the newly founded Russian Geographic Society as publisher on behalf of the Society. But about 1850 the cooperation is discontinued by the Russians, and Froriep, who is in economic difficulties, asks Baer (who lives and works in St. Petersburg) urgently (but in vain) to help him with the Society. (shrink)

Some seeming logical deficiencies in a recent paper are described. The author responds to the arguments of the work by de Muynck, De Baere, and Martens , who argue it is widely accepted today that some sort of nonlocal effect is needed to resolve the problems raised by the works of Einstein, Podolsky, and Rosen and John Bell. In MBM a variety of arguments are set forth that aim to invalidate the existing purported proofs of nonlocality and to provide, (...) moreover, a local solution to the problems uncovered by EPR and Bell. Much of the argumentation in MBM is based on the idea of introducing `nonideal` measurements, which, according to MBM, allow one to construct joint probability distributions for incompatible observables. The existence of a bona fide joint probability distribution for the incompatible observables occurring in the EPRB experiments would entail that Bell`s inequalities can be satisfied, and hence that the mathematical basis for the nonlocal effects would disappear. This relult would apparently allow one to eliminate the need for nonlocal effects by considering experiments of this new kind. (shrink)

In the current debate on art, thought on time has commanded a prominent position. Do we live in a posthistorical time? Has objective art historical time and belief in a continual progress shifted to a more subjective experience of the ephemeral? Has history fallen away and, if so, what does this mean for the future of art? How does a visual archive relate to artistic memory? This volume investigates positions, arguments and comments regarding the stated theme. Philosophers and theorists explore (...) the subject matter theoretically. Curators articulate the practice of art. The participants are: Hans Belting, Jan Bor, Peter Bürger, Bart Cassiman, Leontine Coelewij, Hubert Damisch, Arthur C. Danto, Bart De Baere, Okwui Enwezor, Kasper König, Sven Lütticken, Manifesta, Hans Ulrich Obrist, Donald Preziosi, Survival of the Past Project, Ernst Van Alphen, Kirk Varnedoe, Gianni Vattimo, and Kees Vuyk. (shrink)

Thus begins a letter of an anonymous Pelagian, printed in Patrologia Latino, Suppl. 1.1687–94 from the edition of C. P. Caspari in Briefe, Abhandlungen und Predigten , 3–13. habitationibus is Caspari's emendation for the MSS' laboribus; it gives the right sense, but clashes with habitatione in the next sentence, and is palaeographically unconvincing. J. Baer, De operibus Fastidii, Britannorum episcopi , 31–2 for these reasons suggested litoribus. laboribus itself is not quite impossible, in the sense ‘fields’, ‘estates’ , 147–8, following (...) on Eranos 44 , 347–50). But this usage is late and unrespectable, unless we count the fifth-century Cyprianus Gallus, Gen. 1323 ‘patrios seruare labores'. And we should consider the possibility that our Pelagian wrote laribus. One parallel is Valerius Maximus 7.7.3 ‘in proprio lare’, where lare is Madvig's emendation for iure. More intriguing is a series of passages in Jordane's Getica. (shrink)

Introduction A Brief Conceptual Framework for Biology PART ONE: UNDERSTANDING NATURE 1. The Antecedents of Scientific Thought Animism, Totemism, and Shamanism The Paleolithic View Mesopotamia Egypt 2. Aristotle and the Greek View of Nature The Science of Animal Biology The Parts of Animals The Classification of Animals The Aristotelian System Basic Questions 3. Those Rational Greeks? Theophrastus and the Science of Botany The Roman Pliny Hippocrates, the Father of Medicine Erasistratus Galen of Pergamum The Greek Miracle 4. The Judeo-Christian Worldview (...) The Bishop of Hippo Scholastic Thought Islamic Science Books on Beasts Antecedents of a Revolution 5. The Revival of Science Andreas Vesalius and the Study of Structure William Harvey and the Study of Function Sir Francis Bacon’s Great Instauration Induction, Hypothesis, Deduction The Very Small--Animalcules Robert Hooke and the Discovery of Cells 6. Figur’d Stones and Plastick Virtue Marine Life on Mountain Tops? Figured Stones of Unknown Creatures Baron Cuvier Quarries of the Paris Basin Catastrophism and Uniformitarianism William Smith and the Geological Column Understanding Nature in 1850 PART TWO: THE GROWTH OF EVOLUTIONARY THOUGHT 7. The Paradigm of Evolution First Questions The Paradigm of Natural Theology First Answers 8. Testing Darwins Hypotheses Have Life Forms Changed over Time? Do Species Evolve into Different Species over Time? Has There Been Time Enough for Evolution? Is Natural Selection the Mechanism of Change? The Genetic Basis of Natural Selection Accounting for the Diversity of Life 9. In the Light of Evolution Comparative Anatomy Embryonic Development Classification Microstructure Molecular Processes 10. Life over Time The Origin of Life The Rise of Multicelled Organisms What Is a Phylum? Burgess Shale Metazoans Early Evolution of the Vertebrates The Age of Dinosaurs Birds, Mammals, and Flowering Plants The Rancho La Brea Tar Pits Human Evolution The Role of Extinction in Evolution PART THREE: CLASSICAL GENETICS 11. Pangenesis What Is the Question? Hippocrates and Aristotle The Darwinian Answer Assembling the Data Formulating the Hypothesis by Induction Galton’s Rabbits 12. The Cell Theory The Discovery of Cells: Robert Hooke Schwann and Cells in Animals Gametes as Cells Omnis cellula e cellula? The Technology of Cell Research 13. The Hypothesis of Chromosomal Continuity The Ephemeral Nucleus Schneider, Flemming, and Cell Division The Chromosomes and inheritance Gamete Formation Fertilization 14. Mendel and the Birth of Genetics Model for Monohybrid Crosses Model for Dihybrid Crosses Mendel’s Laws Initial Opposition to Mendelism 15. Genetics + Cytology: 1900-1910 Sutton’s Model The Cytological Basis of Mendel’s Laws Boveri and Abnormal Chromosome Sets Variations in Mendelian Ratios The Discovery of Sex Chromosomes 16. The Genetics of the Fruit Fly Morgan’s First Hypothesis Morgan’s Second Hypothesis The Fly Room Linkage and Crossing-Over The Cytological Proof of Crossing-Over Mapping the Chromosomes The Final Proof The Determinants of Sex The Conceptual Foundations of Classical Genetics 17. The Structure and Function of Genes One Gene, One Enzyme The Substance of Inheritance The Watson-Crick Model of DNA Genes and the Synthesis of Proteins The Genetic Code PART FOUR: THE ENIGMA OF DEVELOPMENT 18. First Principles The Peripatetic Stagirite The Death and Rebirth of Scientific Thought Harvey and Malpighi A Two-Millennial Summing Up Preformation versus Epigenesis 19. The Century of Discovery Von Baer’s Discovery of the Mammalian Ovum Darwin’s Contribution to Embryology Haeckel and Recapitulation 20. Descriptive Embryology Germ Layers The External Development of the Amphibian Embryo The Internal Development of the Amphibian Embryo 21. The Dawn of Analytical Embryology His, Roux, and Mosaic Development Driesch and Regulative Development Novelty in Development Cell Lineage Nucleus or Cytoplasm? Fin de Siècle 22. Interactions during Development Amphibian Organizers Secondary Organizers The Reacting Tissue The Chemical Nature of the Organizer Putting It All Together Conclusion Further Reading References Illustration Credits Index. (shrink)